Comparison results depend on the direction of the comparison. One-way comparisons check the selected objects of Folder1 against the objects in Folder2. Two-way comparisons check objects in Folder1 against those in Folder2 and also check objects in Folder2 against those in Folder1.
A two-way comparison can sometimes reveal information a one-way comparison cannot. A one-way comparison does not note a difference if an object is present in the target folder but not in the source folder.
For example, you have two folders, ADS1 and ADS2, in the same repository. If you compare the folders using a one-way comparison, the source definition ORDER_ITEMS, which is present in ADS2 but not in ADS1, is not noted as a comparison. If you compare the folders using a two-way comparison, the absence of ORDER_ITEMS in ADS1 is noted as a difference.