A file name specified in the session properties is incorrect. The operating system error displays when the file does not exist.
In the Workflow Manager, correct the file name in the session properties.
If you are loading a packaged resource in Metadata Manager, check the value of the PowerCenter Integration Service Process property $PMSourceFileDir. Metadata Manager stores transformed metadata for packaged resources in IME files in the $PMRootDir/SrcFiles directory. If the $PMSourceFileDir property is not set to $PMRootDir/SrcFiles, Metadata Manager cannot find the IME files.