You can remove a domain connection from the PowerCenter Client.
To remove a domain connection:
Click Repository > Configure Domain.
In the Configure Domains dialog box, select the domain connection that you want to delete.
Click the Remove button.
In the warning message that appears, click Yes.
When you remove a domain connection, you terminate connectivity between the PowerCenter Client and all services in the domain. To restore connectivity, add the domain connection, and then add repositories.